Longevity is no longer viewed simply as living longer—it is about living healthier, stronger, and more resilient lives as we age. At the center of this modern understanding lies longevity science, a rapidly evolving field that focuses on cellular energy, inflammation control, and biological balance. NinaPharm stands at the forefront of this movement by advancing research into mitochondrial energy, microbiota interactions, and epigenetic regulation to support optimal health and healthy aging.
The Role of Mitochondria in Longevity
Mitochondria are often described as the “powerhouses” of our cells, but their role in longevity goes far beyond energy production. Healthy, active mitochondria help regulate inflammation, manage oxidative stress, and support cellular repair mechanisms. Through extensive research on centenarians—individuals who live beyond 100 years—NinaPharm demonstrated that exceptional longevity is closely linked to high mitochondrial activity combined with controlled inflammation and stress responses.
These findings shaped NinaPharm’s scientific direction: instead of targeting disease alone, the company focuses on supporting perfect homeostasis, the balanced physiological state observed in long-living populations. This philosophy reflects a shift in longevity science from reactive healthcare toward proactive optimization of health.
Reversed 100: Learning From Centenarians
To further uncover the biological secrets of longevity, NinaPharm launched the “Reversed 100” project, a pioneering initiative aimed at identifying metabolites responsible for the exceptional cellular balance seen in centenarians. By analyzing metabolic patterns rather than symptoms of disease, the research explores how specific metabolites contribute to resilience, energy efficiency, and long-term cellular health.
This innovative approach challenges the traditional “health issue to solution” model and instead focuses on understanding what optimal health looks like at its peak. The result is a deeper insight into how metabolite-based interventions can support longevity at a cellular level.
Microbiota–Mitochondria Axis: A Key to Healthy Aging
One of NinaPharm’s most significant discoveries lies in the microbiota–mitochondria axis, the complex interaction between gut bacteria and cellular energy systems. Through extensive analysis, NinaPharm identified 30 unique bacterial strains, referred to as “super bacteria,” capable of producing a powerful matrix of metabolites that influence mitochondrial performance.
This research moves beyond the simplistic classification of bacteria as “good” or “bad.” Instead, longevity science highlights the importance of distinguishing between a strong and weak microbiome. A resilient microbiome produces metabolites that support mitochondrial function, inflammation control, and metabolic stability—key factors in long-term health and aging.
Epigenetics: Rewriting the Story of Aging
Epigenetic gene regulation plays a critical role in how genes are expressed without altering DNA sequences. Lifestyle factors such as diet, stress, and smoking significantly influence epigenetic markers. Poor lifestyle choices reduce DNA methylation, accelerating aging and increasing the risk of conditions like cardiovascular disease, diabetes, obesity, and chronic respiratory disorders.
NinaPharm’s research shows that epigenetic changes are not permanent. Through targeted metabolite intervention, these markers can be modified and even reversed. Oxy-288 metabolites, developed through advanced longevity science, help increase DNA methylation, thereby repressing the expression of genes associated with aging and chronic disease. This breakthrough opens new possibilities for restoring cellular balance and long-term health.
Proven Performance Under Extreme Conditions
The effectiveness of NinaPharm’s research-backed approach is supported by real-world testing. In a controlled study involving experienced mountaineers operating in extreme high-altitude environments, participants received either Oxy-288 supplementation or a placebo for four weeks before an expedition.
The results were compelling. Those taking Oxy-288 experienced faster recovery, a 21% reduction in cortisol production, and 25% less cell-free mitochondrial DNA, indicating reduced cellular stress and improved mitochondrial resilience. These findings demonstrate how metabolite-based support can enhance energy efficiency even under intense physical and environmental stress.
Innovation Backed by Patented Science
NinaPharm’s commitment to longevity science is further strengthened by the OXYLIA patent, which covers cosmetic and pharmaceutical compositions containing over 50 metabolites designed to increase mitochondrial energy production in healthy cells. This patented innovation reflects the company’s dedication to translating scientific discovery into practical solutions that support longevity, vitality, and optimal homeostasis.
Shaping the Future of Longevity
By combining centenarian research, microbiota science, epigenetics, and mitochondrial energy optimization, NinaPharm is redefining how longevity is understood and supported. Its science-driven approach focuses not merely on extending lifespan, but on enhancing quality of life through cellular resilience, controlled inflammation, and sustained energy.
As longevity science continues to evolve, NinaPharm remains committed to uncovering the biological foundations of healthy aging—empowering individuals to support their long-term health from the inside out.